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Summary

• Gloria has 20 years of experience in conducting research and in lecturing in the fields of biostatistics and research methods, both in academia and industry, in Europe and the USA.
• Her research interests focus on the application of research methods in translational health research, in the continuum space from bench to bedside to population health. Gloria has lead the design, analysis and reporting of several studies in clinical research, epidemiology and population health in a broad spectrum of therapeutic areas including neurology, respiratory diseases, infectious diseases, addiction, hypertension, cardiology, oncology and emergency care.
• The interaction between academia and industry has given Gloria the opportunity to develop a unique ability to synergistically merge the methodological cutting-edge knowledge acquired in the academic/research sector with the high regulatory standards of practices in the commercial sector and to provide strategic knowledge-transfer of advanced statistical methods to both sectors and for a variety of applications including new therapy protocols, drug/medical device/diagnostic commercialization and policy documents for health practices.

Qualifications:

• PhD (Biostatistics and Mathematical Biology), ITT Dublin, Ireland, 2000
• Bachelor of Economics (Statistics and Operation Research), Bocconi University, Milan Italy, 1995
• CStat (Chartered Statistician, nr.108217), Royal Statistical Society, 2003
• Fellow of the Royal Statistical Society, 2003
• CMath (Chartered Mathematician, nr.20311), The Institute of Mathematics and its Applications, 2003
• MIMA (Member of the Institute of Mathematics and its Applications), 2003

Current Positions:

1)      Founder and CEO of StatisticaMedica Ltd. smedica.different.mk  – from 2011 to present

StatisticaMedica is a statistical consultancy company which specialises in the biostatistical and methodological areas of health research, working in the translational space between basic research, clinical and health-related science and practices. StatisticaMedica has its headquarters in Dublin Ireland, with branches in Milan, Italy and Geneva, Switzerland. The company has built relationships with SMEs, large pharma and med devices companies, research institutes, academic and public funded bodies in Ireland and internationally and it focuses its expertise in enhancing the quality of the data and the effective delivery of results in a broad range of applications, in diagnostics, medical devices, pharmaceutical industry, clinical therapy and health care and the food industry.   

StatisticaMedica employs 7 statisticians/data scientists, 2 medical writers, 2 bioinformaticians, 1 project manager and 1 quality management leader. Since 2011 StatisticaMedica has worked on over 80 projects across the pharmaceutical, medical device and diagnostic sectors in a broad spectrum of health research, including neurology, cardiology, respiratory diseases, emergency medicine, obesity and diabetes, medication adherence, and nutrition.

2)      Founder and CEO of Black Channel Ltd. www.black-channel.com – from Jan 2016 to present

Black Channel is an R&D company that combines statistics, mathematics, emergency medicine, data collection, social research, UAS operations, and alpine rescue to advance the use of UAS for medical applications with particular focus on hard-to-reach populations and extreme environments.

Black Channel core expertise is the rigours application of state-of-the science research methodologies to make technology independent assessments and provide regulatory grade evaluations of unmanned aircraft.

Black Channel has conducted trials in Ireland and Italy and it is planning new trials in North and South America.

Previous positions:

1. Professor of Biostatistics and Director of the Data Science Centre at the Royal College of Surgeons of Ireland RCSI –  March 2016 – to March 2017

School of Public Health, RCSI, Dublin, Ireland www.rcsi.ie

Key activities:

·         Carrying out biostatistics research in the field of clinical trials and epidemiology in several therapeutic areas.

·         As director of the new Data Science Centre: setting up the statistical framework to provide statistical support to health research carried out within RCSI Ireland and International (Dubai, Bahrain and Malaysia).

1. Adjunct Professor, the Mathematical Theoretical Biology Institute (MTBI) –  2014-2015  

Simon A. Levin Mathematical, Computational and Modeling Sciences Center (MCMSC)

Arizona State University

Tempe, AZ, USA – https://mcmsc.asu.edu/

Role and responsibilities: lectures and workshops in biostatistics at the Graduate School, Visiting Professor to the Graduate Summer Program at the Mathematical and Theoretical Biology Institute, Co-PI on international research projects in statistics and mathematics applied to health research.

1. Director of CSTAR, the HRB Centre for Support and Training in Analysis and Research, School of Public Health, Physiotherapy and Population Science, UCD, Dublin, Ireland. www.cstar.ie. 2009-2011

1. Lecturer in Statistics and Mathematics, School of Science and Computing, ITT Dublin, Ireland. www.ittdublin.ie   2000-2015

Teaching Deliverables: Lectures in Applied Statistics and Mathematics for Applied Sciences, Pharmaceutical Sciences, Engineering and Business courses, at undergraduate and postgraduate level. Main subjects: Medical Statistics, Industrial Statistics, Mathematical biology, Clinical Research, Statistics for Marketing, Operation Research, Management Science, Calculus and Engineering Mathematics.

1. Senior Statistician, Department of Statistics and Data Management, ICON Clinical Research, Dublin, Ireland. 1999-2000

1. Associate Lecturer in Mathematics and Statistics in the Department of Mathematics and Statistics at NUI Maynooth and in the School of Science and Computing at ITTDublin, Ireland. 1997-1999

1. Multilingual Technical Support Specialist, Iomega Europe, Freiburg, Germany and Dublin, Ireland. IT/Technical support for English, Italian, Spanish and French speaking countries.  1995-1997

Research Grants:

1.         February 2017, Horizon 2020 Fast Track to Innovation grant. A rapid, non-invasive, cost-effective, analytical device for bacterial or viral infection diagnosis through ultra-high sensitivity breath analysis. – 2.3 Million euro (Co-PI).

2.         December 2014, Health Research Awards – Definitive Intervention INCA SUn: A prospective randomised multicentre study to optimise the management of symptomatically uncontrolled asthma – €375,000 (Co-PI).

3.         October 2013, National Children Research Centre (NCRC), Ireland. Collaboration with Prof. Ronan O’Sullivan, Paediatric Emergency Medicine, Our Lady’s Children Hospital Crumlin. Transcriptional Biosignatures in Undifferentiated Febrile Illness in Children. – €271,000 (Co-PI).

4.         September 2013, National Children Research Centre (NCRC), Ireland. Collaboration with Prof. Ronan O’Sullivan, Paediatric Emergency Medicine, Our Lady’s Children Hospital Crumlin. Genomics of Undifferentiated Febrile Illness in Children. – €183,000 (Co-PI).

5.         July 2012, Health Research Board (HRB), Ireland. Collaboration with Dr. Abel Wakai and Prof. Ronan O’Sullivan, Our Lady’s Children Hospital Crumlin. Feasibility Analysis of key performance indicators for emergency departments in Ireland.  – €282,000 (Co-PI).

6.         July 2012, National Children Research Centre  (NCRC), Ireland. Collaboration with Prof. Ronan O’Sullivan, Paediatric Emergency Medicine, Our Lady’s Children Hospital Crumlin. Transcriptional Biosignatures in Undifferentiated Febrile Illness in Children. – €30,000 (Co-PI).

7.         April 2011, National Children Research Centre (NCRC), Ireland. Collaboration with Prof. Ronan O’Sullivan, Paediatric Emergency Medicine, Our Lady’s Children Hospital Crumlin. A Randomised Trial of Single Dose Oral Dexamethasone versus Multi-Dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children who attend the Emergency Department – currently completed recruiting –  €100,000 (Co-PI).

8.         March 2011, FP7 Health (European 7th Framework Programme). Collaboration with Prof. Brian Lawlor, TCD, Ireland. A European multicentre double-blind placebo controlled phase III trial of nilvadipine versus placebo in mild to moderate Alzheimer’s disease – €6,000,000 (Co-PI).

9.         October 2009, UCD Strategic Research and Innovation Fund, Ireland. A statistical and research methods support service for the College of Life Sciences – €50,000 (Co-PI).

10.     2004-2007 European LIFE project: Roma per Kyoto, www.romaperkyoto.org. (2004-2007) – International Advisor and Collaborator.

11.     December 2007, HEA, Ireland – Strand III. Collaboration with the CMHI Research Centre at ITTDublin, Ireland. Microbial Pathogenesis:  Evaluation of the interactions between Cystic Fibrosis pathogens and lung cells with a view to identifying novel therapeutic targets – €400,000(Co-PI).

12.     May 2006, HEA, Ireland – Strand I, MSc grant. Role of drug treatment and altered adenine nucleotide metabolism in preventing stroke. Collaboration with Dr.D Egan of CPRD, ITTDublin, Ireland and Dr.D. McCabe, Tallaght Children Hospital, Ireland –  €32,000 (Co-PI).

13.     September 2005, HEA, Ireland – Strand I, MSc grant. Collaboration with Prof. C. Castillo-Chavez at the Mathematics and Statistics Department of Arizona State University and the Chemometrics Department of GlaxoSmithKline, UK. Development of a mathematical tool for the in-line monitoring of a chemical process and the prediction of large scale pharmaceutical processes – €32,000 (PI).

14.     March 2004, Enterprise Ireland, International Collaboration Programme, 2004. Visitorship to the Biostatistics and Epidemiology Department, at Harvard School of Public Health. €3,800 (PI).

15.     June 2002, The National Advisory Committee on Drugs (NACD), Ireland. Research Outcome Study in Ireland Evaluating Drug Effectiveness (ROSIE study). Collaboration with Dr. C. Comiskey (NUI Maynooth) – €650,000 (Co-PI).

16.     June 2001, Research and Development Seed Fund 2001, The Institute of Technology Tallaght, Ireland. The Mathematical and Statistical Analysis of Infectious Diseases – IR£3,000 (€3,810) (PI).

17.     June 2001, Post-graduate R&D Skills Programme in Institute of Technologies, Ireland. Collaboration with  Dr. G.Colleran, School of Science, I.T.Tallaght, Analysis of the microbial contamination of street heroin in Dublin – IR£29,300 (€32,000) (Co-PI).

18.     June 2000, Enterprise Ireland, Post-Doctoral Scholarship. Dynamics of multiple strain meningococcal bacteria. Spread of infection and effect of vaccination. IR£40,000 (€50,800) (PI).

19.     February 1998, Enterprise Ireland, International Collaboration Programme 1998 (PI). Visitorship to the Biometrics Department of Cornell University, Ithaca, NY, USA. Collaborator Prof. Castillo-Chavez, Chairman of the Biometrics Department. IR£3,000 (€3810) awarded.

20.     June 1997, Graduate Training Programme January 1997- May 1999 (Co-PI), the Government Operational Programme for Industrial Development by the Council of Directors of Institute of Technologies.IR£13,500 (€17,145) awarded.

National and International Profile:

Recent collaborations with centres of excellence nationally and internationally, including:

• • • Simon A. Levin Mathematical, Computational and Modeling Sciences Center (MCMSC) at Arizona State University (USA)
    • The Research Triangle Institute RTI International (USA)
    • The Department of Health Economics of the University of North Carolina, UNCG (USA)
    • The department of Mathematics of Montclair State University, NJ (USA)
    • The National Children Research Centre, Crumlin (Ireland)
    • Trinity College Dublin – the School of Nursing and the School of Bioingeneering – (Ireland)
    • UCD School of Medicine and Health (Ireland)
    • The National Advisory Committee on Drugs and Alcohol, NACDA (Ireland)
    • The Statistics Department at Bocconi University, Milan (Italy)
    • The Biometrics Department of Cornell University (USA) – from 1998 to 2000
    • The Harvard School of Public Health (USA), – 2001
    • ENEA – Ente Nazionale per le Energie Alternative (Italy) – from 2006 to 2009

§  Centre of Microbial Hosting Interactions, CMHI, ITTDublin (Ireland)

§  Centre for Pharmaceutical R&D (CPRD), ITTDublin (Ireland)

§  The Mathematics and Statistics Department, NUIM, (Ireland) – from 2002 to 2005

Recent Publications, Chapters, Conference Proceedings, Research-based Reports, Policy Documents:

Sulaiman, MC Mokoka, E MacHale, J Seheult, C Hughes, M Holmes, S D’arcy, T Taylor, V Rapcan, D Murphy, E Hunt, SJ Lane, A Sahadevan, G Crispino, GB Diette, A Sartini-Bhreathnach, B Cushen, I Killane, RB Reilly, RW Costello (2017). Behavioural feed-back education intervention to enhance adherence in patients with severe uncontrolled asthma, a randomised clinical trial. Thorax BMJ 2017; 72 287-287.

I Sulaiman, E Mac Hale, M Holmes, C Hughes, S D’Arcy, T Taylor, V Rapcan, F Doyle, A Breathnach, J Seheult, D Murphy, E Hunt, SJ Lane, A Sahadevan, G Crispino, G Diette, I Killane, RB Reilly, RW Costello (2016). A protocol for a randomised clinical trial of the effect of providing feedback on inhaler technique and adherence from an electronic device in patients with poorly controlled severe asthma. BMJ Open 2016;6:e009350. doi: 10.1136/bmjopen-2015-009350

Hamilton C, D’Arcy S, Pearlmutter BA, Crispino G, Lalor EC, Conlon BJ (2016). An Investigation of Feasibility and Safety of Bi-Modal Stimulation for the Treatment of Tinnitus: An Open-Label Pilot Study: bi-modal stimulation for tinnitus. Neuromodulation. 2016 Dec;19(8):832-837.

Murphy AP, Hughes M, Mccoy S, Crispino G, Wakai A, O’Sullivan R (2016). Intranasal fentanyl for the prehospital management of acute pain in children. Eur J Emerg Med. 2016 Mar 15

Sheridan-Pereira, MI; Murphy, J; Sloan, J; Crispino, G; Leahy, A; Corcoran, J D; Dempsey, E; Elnazir B; Gavin, P; Sharif, F; Gul, R; Satas, S; Murphy, J; Gormally, S; Shanaa, I; Waldron, D; Mc Mahon, P; Carson, J; Blanken, M; Bont, L; Paes, B. (2016). Syncytial Virus Preterm (32-36 Completed Weeks Gestation) Risk Estimation Measure for RSV Hospitalization in Ireland: A Prospective. The Paediatric Infectious Disease Journal January 2016, Pediatr Infect Dis J. 2016 Jan;35(1):19-24.

A Murphy, S McCoy , K O’Reilly, E Fogarty, J Dietz , G Crispino, A Wakai, R O’Sullivan (2016). A Prevalence and Management Study of Acute Pain in Children Attending Emergency Departments by Ambulance. Prehosp Emerg Care. 2016;20(1):52-8.

J Cronin, S McCoy, U Kennedy, S Nic an Fhailí, A Wakai, J Hayden, G Crispino, M Barrett, S Walsh, R O’Sullivan (2015). A Randomized Trial of Single-Dose Oral Dexamethasone Versus Multidose Prednisolone for Acute Exacerbations of Asthma in Children Who Attend the Emergency Department. Annals of Emergency Medicine 2015; 44(15). doi:10.1016/j.annemergmed.2015.08.001

L Oosthuizen, M A Mc Aleer, R M Watson, G M O’Regan, A Byrne, G Crispino-O’Connell and A D Irvine (2015). Nottingham Eczema Severity Scoring tool can identify children at high risk of food allergy to cow’s milk, egg and peanut. Clin Transl Allergy. 2015; 5(Suppl 3): P127.

J Simmond, H Murchan, A James, G Crispino, J O’Brien, K Crumlish, O Franklin, M Fenton, M Burch, Colin J. McMahon (2015). Outcome of shared care for pediatric cardiac transplantation between two nations with different healthcare systems. The Journal of Heart and Lung Transplantation Volume 34, Issue 6, June 2015, Pages 806–814.

Brenner M, Hilliard C, Peel G, Crispino G, Geraghty R, O’Callaghan G (2014). Management of Pediatric Skin-Graft Donor Sites: A Randomized Controlled Trial of Three Wound Care Products. Journal of Burn Care & Research., Post Copyedit: September 2, 2014.

Jansen N Seheult, P O’Connell, Kee Chun Tee, T Bholah, H Al Bannai, I Sulaiman, E MacHale, S D’Arcy, MS Holmes, D Bergin, E Reeves, RB Reilly, G Crispino-O’Connell, C Ehrhardt, A Healy, RW Costello (2014). The Acoustic Features of Inhalation can be Used to Quantify Aerosol Delivery from a Diskus™ Dry Powder Inhaler. Pharmaceutical Research 05/2014.

SM O’Donnell, J Pollock, P O’Connor, PV Baranov, G Crispino, S Walsh, A Wakai, R O’Sullivan (2014) Peripheral blood RNAs may differentiate bacterial from viral febrile illness in infants. Irish Journal of Medical Science 183:476-477 • October 2014

C. Hamilton, B. Pearlmutter , B. Conlon and G. Crispino (2014). Impact of acoustic and tactile multi-modal neuromodulation on objective and subjective measures of tinnitus. Abstracts of the Fourth Joint Annual Conference, Experimental and Clinical Short Papers Meetings of the British Society of Audiology, International Journal of Audiology 2014; 53: 641–696.

This link is wrong Jansen N Seheult, P O’Connell, Kee Chun Tee, T Bholah, H Al Bannai, I Sulaiman, E MacHale, S D’Arcy, MS Holmes, D Bergin, E Reeves, RB Reilly, G Crispino-O’Connell, C Ehrhardt, A Healy, RW Costello (2014). The Acoustic Features of Inhalation can be Used to Quantify Aerosol Delivery from a Diskus™ Dry Powder Inhaler. Pharmaceutical Research 05/2014.